Idr-containing protein
Web2 feb. 2016 · A protein called nucleophosmin is found at high levels in the nucleolus where it interacts with many other proteins, including those involved in making ribosomes. Nucleophosmin binds to motifs within these proteins that contain multiple copies of an amino acid called arginine (referred to as R-motifs). Web22 jul. 2024 · Proteins that form condensates often contain intrinsically disordered regions (IDRs), long spaghetti-like strands that transiently stick together to form a dynamic mesh. Research has historically...
Idr-containing protein
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The densely packed eukaryotic cellular interior is comprised of numerous compartments or organelles. These compartments enable spatiotemporal control over … Meer weergeven National Key Research and Development Program of China [2024YFA0507504, 2024YFA0505503]; National Natural Science Foundation of China [61773025, 31871343]; … Meer weergeven PhaSepDB is constructed based on the curated information derived from published literature after two rounds of manual verification … Meer weergeven The emergence of the concept that LLPS underlies cellular compartmentalization formation has expanded our understanding … Meer weergeven Web23 jul. 2024 · The presence of these larger structures could indicate that at very high concentrations MUT-16 is behaving more solid or gel-like, which has been seen previously for some IDR-containing proteins . These data indicate that overexpression of MUT-16 in muscle cells is sufficient for somatic foci formation and suggest that MUT-16 can form …
Web3 dec. 2024 · Although the disordering tendency shows a set of proteins containing IDR, each corresponding diagram phase indicates a small tendency to phase separate. As … WebPhase separation is an important mechanism that mediates the compartmentalization of proteins in cells. Proteins that can undergo phase separation in cells share certain …
WebThe interaction of the β-coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid (N) protein with genomic RNA is initiated by specific RNA regions and subsequently... Web27 sep. 2024 · Although such intrinsically disordered regions (IDRs) are generally small [less than 100 amino acids] they are surprisingly abundant and have important functions in the …
Web31 mrt. 2024 · These results demonstrate that light-induced clustering of IDR-containing protein complexes activates endogenous gene transcription at native chromatin. …
Web50 cally disordered regions (IDRs) of proteins, such as electro-51 static, cation-π, and π-π interactions, play crucial roles in 52 LLPS.5,6 For instance, binding of the IDR … teachers oat teachersWeb24 sep. 2015 · Intrinsically disordered regions (IDRs) of RNA-binding proteins can phase separate • RNA, crowding agents, and low salt promote IDR phase separation • Phase-separated droplets stabilize over time by formation of amyloid-like fibers • Multiple IDRs can be recruited to phase-separated droplets Summary teachers objectivesWeb22 jan. 2024 · The IDR-containing N-terminus of Nucleoporin 98 (NUP98) is fused to >30 partners, and NUP98-fusion-expressing AML is associated with poor prognosis. While … teachers oath to studentsWeb8 jul. 2016 · Intrinsically disordered regions (IDRs) are peculiar stretches of amino acids that lack stable conformations in solution. Intrinsic Disorder containing Proteins (IDP) are … teachers objectives for teachingteachers objectives for appraisalWeb24 feb. 2014 · Each protein had between 4–7 orthologs among chimp, dog, mouse, rat, fly, worm and yeast . This dataset has been previously used to show the relationship … teachers oay teacher networkWebUpper panel shows the solubilities of full-length proteins (white bar) and IDR-removed proteins (red bar) for ten IDR-containing proteins in their N-terminus (Clb3, Cmr1, … teachers observation checklist