Splet16. feb. 2024 · The AurkA kinase is a well-known mitotic regulator, frequently overexpressed in tumors. The microtubule-binding protein TPX2 controls AurkA activity, localization, and … SpletTPX2 is an effector of microtubule nucleation in spindles, and functions with the 18 substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase separates …
Phase Separation in Cell Division - ScienceDirect
Splet17. jul. 2024 · A Western blot analysis revealed that TPX2 protein expression was high at the G2/M phase, decreased at the G1 to S phase, increased at the beginning of S phase, and then peaked again at the next G2/M phase (Figure 3A). TPX2 depletion reduced the G1- and S-phase proportions; by contrast, inhibition of TPX2 expression resulted in high amounts … Splet12. maj 2024 · Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability . Authors Chao-Wen Hsu 1 2 , Yu-Chia Chen 3 , Hsing-Hao Su 4 , Guan-Jin Huang 5 , Chih-Wen Shu 6 , Tony Tong-Lin Wu 3 2 , Hung-Wei Pan 6 Affiliations ceo of apartments.com
Phase separation of TPX2 enhances and spatially …
Splet12. jun. 2024 · TPX2 is an effector of microtubule nucleation in spindles, and functions with the substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase … Splet01. mar. 2009 · During the latter stages of the execution phase, actin–myosin-II drives the movement of apoptotic nuclear fragments into surface blebs (Lane et al., ... TPX2 siRNA: … Splet28. mar. 2024 · Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement. Consequently, CD44 demarks stem cells in normal tissues and tumor-initiating cells isolated from neoplastic tissues. Hyaluronan mediated … buy orleans