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Tpx2 phase

Splet16. feb. 2024 · The AurkA kinase is a well-known mitotic regulator, frequently overexpressed in tumors. The microtubule-binding protein TPX2 controls AurkA activity, localization, and … SpletTPX2 is an effector of microtubule nucleation in spindles, and functions with the 18 substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase separates …

Phase Separation in Cell Division - ScienceDirect

Splet17. jul. 2024 · A Western blot analysis revealed that TPX2 protein expression was high at the G2/M phase, decreased at the G1 to S phase, increased at the beginning of S phase, and then peaked again at the next G2/M phase (Figure 3A). TPX2 depletion reduced the G1- and S-phase proportions; by contrast, inhibition of TPX2 expression resulted in high amounts … Splet12. maj 2024 · Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability . Authors Chao-Wen Hsu 1 2 , Yu-Chia Chen 3 , Hsing-Hao Su 4 , Guan-Jin Huang 5 , Chih-Wen Shu 6 , Tony Tong-Lin Wu 3 2 , Hung-Wei Pan 6 Affiliations ceo of apartments.com https://charlotteosteo.com

Phase separation of TPX2 enhances and spatially …

Splet12. jun. 2024 · TPX2 is an effector of microtubule nucleation in spindles, and functions with the substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase … Splet01. mar. 2009 · During the latter stages of the execution phase, actin–myosin-II drives the movement of apoptotic nuclear fragments into surface blebs (Lane et al., ... TPX2 siRNA: … Splet28. mar. 2024 · Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement. Consequently, CD44 demarks stem cells in normal tissues and tumor-initiating cells isolated from neoplastic tissues. Hyaluronan mediated … buy orleans

Phase separation of TPX2 enhances and spatially coordinates

Category:Subcellular - TPX2 - The Human Protein Atlas

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Tpx2 phase

Phase separation of TPX2 enhances and spatially coordinates.

SpletKing MR, Petry S. Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation. Nat Commun 2024;11 (1):270. Abstract 2024 Thawani A, Stone HA, Shaevitz JW, Petry S. Spatiotemporal organization of branched microtubule networks. Elife 2024;8 Abstract 2024 Splet14. jan. 2024 · Here we show that TPX2 phase separates into a co-condensate with tubulin, which mediates microtubule nucleation in vitro and in isolated cytosol. TPX2-tubulin co …

Tpx2 phase

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Splet13. mar. 2024 · Microtubules are essential for regulating cell morphogenesis, plant growth, and the response of plants to abiotic stresses. TPX2 proteins are the main players … http://aammt.tmmu.edu.cn/Upload/rhtml/202410154.htm

SpletTPX2 is highly expressed in G2/M phase, human hepatocellular carcinoma tissues and cancer cell lines. We obtained 9 pairs of hepatocellular carcinoma (T) and non-tumorous … Splet10. apr. 2024 · Bottom row, representative raw images of G2/M phase cells separated on PHATE coordinates. All images show mRNAs (white) in HeLa cells (DAPI in blue). ... G2/M genes: TOP2A, TPX2, UBE2C, HJURP ...

Splet14. jan. 2024 · TPX2-tubulin co-condensation preferentially occurs on pre-existing microtubules, the site of branching microtubule nucleation, at the endogenous and … SpletTPX2 is an effector of microtubule nucleation in spindles, and functions with the substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase separates into a co …

Splet12. jun. 2024 · TPX2 is an effector of microtubule nucleation in spindles, and functions with the substrate tubulin by an unknown mechanism. Here, we show that TPX2 phase separates into a co-condensate with tubulin, which mediates microtubule nucleation in vitro and in isolated cytosol.

Splet28. jan. 2024 · TPX2 was flash frozen in liquid nitrogen and stored at −80 °C until use. This TPX2 was used for all fluorescence, electron and atomic force microscopy experiments. ceo of apple 2018SpletInteraction of spindle assembly factor TPX2 with importins-α/β inhibits protein phase separation. The microtubule-based mitotic spindle is responsible for equally partitioning … buy or lease analysisSplet01. okt. 2003 · The complex between human phosphorylated AuroraΔN and TPX2 1–43 is active in histone H3 phosphorylation (Figure 2C, lane 7).The polypeptide model includes the catalytic core of the kinase (residues 123–387 AUR) and two segments of TPX2 (residues 7–21 TPX and 30–43 TPX).No ordered electron density is present for the 8 intervening … ceo of apple 2000Splet01. maj 2003 · It is found that TPX2 acts to suppress tubulin subunit off-rates during microtubule assembly and disassembly, thus allowing for the support of unprecedentedly slow rates of plus-end microtubules growth, and also leading to a dramatically reduced microtubULE shortening rate. Expand 38 PDF View 1 excerpt, cites background Save Alert ceo of apple 2019SpletTPX2 can undergo phase transition to form liquid-like droplets. This droplet formation is thought to enhance TPX2’s ability to promote microtubule nucleation by increasing the … buy or lease a honda civic bad credit redditSpletHPA005487. BJ [Human fibroblast] Image. Immunostaining of TPX2 in BJ primary cells displaying a strong staining in the mitotic spindle as well as a weaker nuclear staining in a subset of the cells. SINGLE CELL VARIATIONi. Assays for determining cell cycle dependency of RNA and protein expression, based on stainings in the U-2 OS FUCCI ... ceo of aramark corpSpletPhase separation of substrates and effectors is proposed to enhance biological reaction rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching … buy or lease a car 2023